Author: TG and FE Marshall (---.vnnyca.adelphia.net)
Date: 07-10-03 23:41
Significance of Interferon-gamma in the Th1 Immune Reaction
Authors: Trevor G Marshall, PhD, and Frances E Marshall, RPh
Authors Affiliation: SarcInfo, Thousand Oaks, California 91360
email corresponding author: Trevor. m@yarcrip.com
Date Published: 20 March 2003
Article Type: Letter
Comment upon: Aoe K, Hiraki A, Murakami T, Eda R, Maeda T, Sugi K, Takeyama H: Diagnostic Significance of Interferon-γ in Tuberculous Pleural Effusions. Chest 2003; 123: 740-744 [PMID: 12628872]
From the perspective of a biochemist, the Th1 immune reaction, which is mounted by the immune system when challenged by gram-negative bacteria [1], has Interferon-γ as a key element in its proliferation [2].
We have proposed a working description for the proliferation of Th1 immune biochemistry, based on our studies of Sarcoid patients. It outlines the most probable role played by the secosteroid hormone 1,25-dihydroxyvitamin D in Th1 inflammatory proliferation [3]. The actions of 1,25-dihydroxyvitamin D and Interferon-γ are symbiotic [2].
We would therefore urge that any future studies of Tuberculosis Pleural Effusion should monitor the levels of 1,25-dihydroxyvitamin D along with Interferon-γ. Parameters to monitor are discussed in [3], and also in our Electronic Letter, "The Science Points to Angiotensin II and 1,25-Dihydroxyvitamin D" [4].
References:
1. Lai CK, Ho S, Chan CH, Chan J, Choy D, Leung R, Lai KN: Cytokine gene expression profile of circulating CD4+ T cells in active pulmonary tuberculosis. Chest 1997 Mar;111(3): 606-11 [Abstract] [Full Text]
2. Vidal M, Ramana CV, Dusso AS: Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription. Mol Cell Biol 2002; 22(8): 2777-87 [PubMed Abstract][Full Text]
3. Marshall TG, Marshall FE: New Treatments Emerge as Sarcoidosis Yields Up its Secrets. Clinmed 2003 Jan 27; 2003010001.
(accessed 27 Jan 2003) [Full Text]
4. Marshall TG, Marshall FE: The Science Points to Angiotensin II and 1,25-Dihydroxyvitamin D. [Electronic Letter] Chest 6 Feb 2003; Available from URL http://www.chestjournal.org/cgi/eletters/123/1/18
FOOTNOTES
No agency funded this research
Competing Interests: None Declared
KEYWORDS
Tuberculosis
Sarcoidosis
interferon-gamma
angiotensin II
acid-fast bacteria
cell-wall-deficient bacteria
lupus erythematosus, cutaneous
MeSH CLASSIFICATIONS
Tuberculosis
Sarcoidosis
Atypical Bacterial Forms
Transformation, Bacterial
Lupus Erythematosus, Cutaneous
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